Mass spectrometry services have become integral to drug discovery and development. Mass spec services have helped drug developers accelerate drug development timelines by contributing valuable insights into drug discovery and innovation.
A typical mass spectrometer includes an ion source, an analyzer, and a detector. Besides, hyphenated techniques such as liquid chromatography-mass spectrometry have made LC-MS services critical for analyzing small and large-molecule drug products. The current article explores mass spectrometry analysis services for analyzing drug compounds.
Mass spectrometry services
Mass spectrometry service companies are vital for developing therapeutics. Mass spectrometry services help drug developers generate reliable data, from pharmacokinetic studies to preclinical and clinical assessments. . Besides, many mass spectrometry service companies have various analyte detection capacities, including proteins, peptides, glycoconjugates, and glycoproteins.
Mass spectrometry services have extensive experience supporting drug characterization studies, including large molecule drug products. Besides, they have a robust combination of managing complex projects with state-of-the-art infrastructure to support high-quality proteomic and structural characterization studies. Mass spectrometry services have numerous applicability in drug research, including:
- Peptide mapping
- Glycan structural characterization
- Molecular weight determination
- Glycosylation site mapping
- Quantitative proteomics
- Identification and quantification of post-translational modifications
- Isoform characterization
- Disulfide bond mapping
- Biosimilar characterization programs
- Stability studies
Mass spectrometry techniques
Mass spectrometry is a unique technique that can be combined with different bioanalytical tools such as gas chromatography, liquid chromatography, and inductively coupled plasma systems. Let us study each of these combinations in more detail.
GC-MS systems can analyze volatile and semivolatile compounds. They are ideal for small organic molecule analysis. LC-MS systems can detect numerous organic analytes. These organic analytes may also include nonvolatile and large compounds. LC-MS systems can help identify unknown compounds and confirm chemical structures. Besides, with alternatives such as UPLC and LC-MS/MS units, LC-MS systems have numerous uses, such as analyzing surfactants, degradation products, and impurities.
On the other hand, inductively coupled plasma mass spectrometers can measure inorganic compounds. The mass spectrometer is critical for confirming assay components and assessing extractible or identifying deformations, making them a crucial bioanalytical technique.
Applications of mass spectrometry services
Mass spectrometry services have numerous applications in the biological, industrial, pharmaceutical, and agrochemical fields. For example, in a pharmaceutical setting, several drug developers use antibodies to assess the ability of a drug to reach its target area. The sequence of this antibody should be accurate. Mass spectrometry can help identify the accuracy of this protein sequence.
In an academic environment, researchers often synthesize peptides. However, the sequence and overall mass should be understood adequately before its applications. Researchers employ an intact mass analysis method to detect the purity of small peptides before investigation. Moreover, proteins are present in all biological samples. Hence mass spectrometry services have newer applications when it comes to protein-based analysis.
Mass spectrometry analysis has numerous applications. However, finding a reliable mass spectrometry service company that provides dependable and fast results is key. Notably, identifying the expertise of a mass spectrometry service provider will remain crucial for identifying reliable partner laboratories.